Description

Tesamorelin is a synthetic 44-amino acid peptide and a stabilized analog of human growth hormone-releasing hormone (GHRH). By incorporating a hexenoyl moiety at its N-terminus, Tesamorelin is engineered for increased resistance to enzymatic degradation. This research-grade compound is used to study the stimulation of pulsatile endogenous growth hormone (GH) secretion and its effects on visceral adiposity.

• Purity: >99% (HPLC Tested)

• Format: Lyophilized White Powder

• Molecular Formula: C221H366N72O67S1

• Research Target: Pituitary GH Pulsatility & Visceral Lipolysis

Tesamorelin is frequently utilized in endocrine research to investigate the restoration of youthful growth hormone dynamics. Unlike direct GH administration, Tesamorelin re-engages the hypothalamic-pituitary-growth hormone (HPGH) axis, resulting in the intermittent, pulsatile release of GH and downstream production of IGF-1.

Research Observed Outcomes

• 10–20% Visceral Fat Reduction: In 26-week controlled trials, subjects demonstrated a significant reduction in Visceral Adipose Tissue (VAT) compared to placebo.

• Hepatic Fat Clearance: Exploratory research showed a relative liver fat reduction of 37% in subjects over 12 months.

• Lipid Profile Improvement: Sustained treatment has been associated with a mean reduction in triglycerides of approximately 50 mg/dL.

• Preservation of Glucose Homeostasis: Research shows that while IGF-1 increases, HbA1c levels typically remain within stable parameters.

Key Linked Studies & Research References

• Visceral Adiposity: Falutz J, et al. (2007). “A Placebo-Controlled Study of a Growth Hormone–Releasing Factor for HIV-Associated Abdominal Fat Accumulation.” NEJM.

• Hepatic Fat: Spooner S, et al. (2019). “Tesamorelin reduces intrahepatic fat content and prevents progression of liver fibrosis.” The Lancet HIV.

• GH Pulsatility: Teichman S, et al. (2006). “Prolonged stimulation of GH and IGF-I secretion by TH9507.” Journal of Clinical Endocrinology & Metabolism.

Storage & Stability Protocols

• Lyophilized Powder: Store at -20°C. Stable at room temperature for transit.

• Reconstituted Stability (Bacteriostatic Water): Stability is maintained for 4–6 weeks when refrigerated (2°C – 8°C).

• Reconstituted Stability (Sterile Water): Stability is shorter, typically 7–12 days.

• Handling: Avoid excessive agitation or repeated freeze-thaw cycles.

⚠️ STRICT COMPLIANCE NOTICE: FOR LABORATORY RESEARCH ONLY This product is a chemical substance intended strictly for in vitro or laboratory experimentation. Any form of ingestion, injection, or topical application to humans or animals is STRICTLY PROHIBITED. This product is not a drug, food, or cosmetic and has not been approved by the FDA for any medical application.