Description

SS-31 (Elamipretide) – 10mg

SS-31, also known as Elamipretide, is a mitochondria-targeting tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) designed to selectively bind to cardiolipin within the inner mitochondrial membrane. It is studied extensively in laboratory settings for its role in mitochondrial bioenergetics, oxidative stress modulation, and membrane stabilization.

This peptide is engineered strictly for laboratory investigation into mitochondrial dysfunction, ATP production efficiency, and reactive oxygen species regulation.

Purity: >99% (HPLC Tested)
Format: Lyophilized White Powder
Molecular Formula: C32H49N9O5
Research Target: Mitochondrial Cardiolipin & Electron Transport Chain Stability

SS-31 is unique in that it localizes directly to mitochondria independent of membrane potential. In research models, it binds cardiolipin to stabilize cristae structure and optimize electron transport chain efficiency. This interaction reduces excess reactive oxygen species production while improving ATP synthesis under stress conditions.

Research Observed Outcomes

Data from mitochondrial and metabolic research programs highlight the following findings in controlled laboratory models:

Improved ATP Production:
SS-31 has been shown to enhance mitochondrial respiration efficiency and restore ATP output in dysfunctional mitochondria models.

Reduced Reactive Oxygen Species:
Laboratory investigations demonstrate decreased mitochondrial ROS generation during oxidative stress conditions.

Cardiolipin Stabilization:
Research indicates preservation of mitochondrial membrane integrity and cristae structure.

Ischemia-Reperfusion Protection Research:
Experimental models show reduced cellular damage markers following metabolic stress challenges.

Enhanced Muscle & Cardiac Bioenergetics Research:
Preclinical studies suggest improved mitochondrial efficiency in skeletal and cardiac tissue models.

Key Linked Studies & Research References

Mitochondrial Targeting Mechanism:
Szeto, H.H., et al. (2011). “Mitochondria-targeted peptide SS-31 protects against oxidative damage.” Journal of the American Society of Nephrology.

Cardiolipin Interaction Research:
Birk, A.V., et al. (2013). “Targeting mitochondrial cardiolipin and the role of SS-31.” Journal of Molecular and Cellular Cardiology.

Oxidative Stress & Bioenergetics:
Zhao, K., et al. (2004). “A mitochondria-targeted antioxidant peptide.” Proceedings of the National Academy of Sciences.

Clinical Translation Studies:
Dai, D.F., et al. (2014). “Mitochondrial oxidative stress in aging.” Circulation Research.

Storage & Stability Protocols

To preserve peptide integrity and mitochondrial-targeting properties:

Lyophilized Powder:
Store at -20°C for long-term stability. Stable at room temperature for short-term transit.

Reconstituted Stability (Bacteriostatic Water):
When reconstituted under sterile laboratory conditions, solution stability is typically maintained for 4–6 weeks under refrigeration (2°C – 8°C).

Reconstituted Stability (Sterile Water):
Stability is significantly shorter, typically 7–12 days due to absence of antimicrobial preservatives.

Handling:
Avoid repeated freeze-thaw cycles. Protect from excessive heat, light, and agitation during reconstitution.

⚠️ STRICT COMPLIANCE NOTICE: FOR LABORATORY RESEARCH ONLY
This product is a chemical research peptide intended strictly for in vitro or laboratory experimentation. Any form of ingestion, injection, or topical application to humans or animals is STRICTLY PROHIBITED. This product is not a drug, food, or cosmetic and has not been approved by the FDA for any medical application. Handling must be performed by qualified professionals in controlled laboratory environments.