Description

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid mitochondrial-derived peptide (MDP). It is a key regulator in metabolic research, specifically focusing on mitochondrial signaling, glucose homeostasis, and cellular longevity. This peptide is engineered for laboratory investigation into mitochondrial-to-nuclear communication and its role in protecting cells against metabolic stress and age-related decline.

• Purity: >99% (HPLC Tested)

• Format: Lyophilized White Powder

• Molecular Formula: C101H152N28O22S2

• Research Target: Mitochondrial Bioenergetics & Insulin Sensitivity

MOTS-C represents a frontier in “mitohormetic” research. It is unique because it is encoded within the mitochondrial genome rather than the nuclear genome. In research models, MOTS-C has been observed to translocate to the nucleus during metabolic stress, where it regulates nuclear gene expression to optimize energy expenditure. This mechanism makes it a primary subject of study for reversing mitochondrial dysfunction, enhancing fatty acid oxidation, and investigating the pathways of metabolic flexibility.

Research Observed Outcomes

Data from aging and metabolic research programs highlight the following physiological impacts in test models:

• Enhanced Glucose Metabolism: MOTS-C research indicates a significant increase in glucose uptake by skeletal muscle through the activation of the AMPK (AMP-activated protein kinase) pathway.

• Reduction in Fat Accumulation: Studies in diet-induced metabolic stress models observed a decrease in weight gain and white adipose tissue accumulation.

• Improved Insulin Sensitivity: Research demonstrates that MOTS-C may prevent insulin resistance caused by high-fat diets by improving systemic insulin signaling.

• Mitochondrial Biogenesis: Laboratory data suggests MOTS-C stimulates the formation of new mitochondria, effectively “refreshing” cellular energy production.

• Physical Capacity Increase: In murine models, MOTS-C administration has been linked to increased physical endurance and a reversal of age-related physical decline.

Key Linked Studies & Research References

• Discovery & Metabolism: Lee, C., et al. (2015). “The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance.” Cell Metabolism.

• Endurance & Aging: Reynolds, J.C., et al. (2021). “MOTS-c is an exercise-induced DNA-binding hormone that promotes metabolic homeostasis and healthy aging.” Nature Communications.

• AMPK Pathway Activation: Zarse, K., & Ristow, M. (2015). “A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance.” Cell Metabolism Reviews.

• Cellular Longevity: Kim, S.J., et al. (2018). “Mitochondrial peptides: an emerging family of intracellular and extracellular regulators.” Trends in Endocrinology & Metabolism.

Storage & Stability Protocols

To maintain the structural integrity of this mitochondrial peptide, the following storage guidelines are recommended:

• Lyophilized Powder: Store at -20°C for long-term stability. The dry powder is stable at room temperature for short-term transit.

• Reconstituted Stability (Bacteriostatic Water): Once reconstituted, the solution typically maintains stability for 4–6 weeks when refrigerated (2°C – 8°C).

• Reconstituted Stability (Sterile Water): Stability is significantly shorter, typically 7–12 days, due to the absence of antimicrobial preservatives.

• Handling: MOTC is highly sensitive to temperature fluctuations. Minimize time out of cold storage and avoid vigorous agitation during reconstitution.

⚠️ STRICT COMPLIANCE NOTICE: FOR LABORATORY RESEARCH ONLY This product is a chemical substance intended strictly for in vitro or laboratory experimentation. Any form of ingestion, injection, or topical application to humans or animals is STRICTLY PROHIBITED. This product is not a drug, food, or cosmetic and has not been approved by the FDA for any medical application. Handling should only be performed by qualified professionals in a controlled environment.